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BPS Bioscience
idh2 r140q assay kit  Idh2 R140q Assay Kit, supplied by BPS Bioscience, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/result/idh2 r140q assay kit/product/BPS Bioscience Average 93 stars, based on 1 article reviews
idh2 r140q assay kit - by Bioz Stars,
2026-03
93/100 stars
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Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Article Title: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
doi: 10.1080/14756366.2022.2157411
Figure Lengend Snippet: Function of wild-type IDH in homeostasis and activity of mutant IDH in disease. α-KG, α-ketoglutarate; 2-HG, D-2-hydroxyglutarate; D2HGDH, D-2-hydroxyglutarate dehydrogenase; IDH, isocitrate dehydrogenase; IDH2m, mutant IDH2.
Article Snippet: Assay of IDH2 R140Q enzyme inhibition was performed using the fluorimetry-based assay according to manufacturer’s procedure of
Techniques: Activity Assay, Mutagenesis
Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Article Title: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
doi: 10.1080/14756366.2022.2157411
Figure Lengend Snippet: Chemical structures of representative mutant IDH2 R140Q inhibitors.
Article Snippet: Assay of IDH2 R140Q enzyme inhibition was performed using the fluorimetry-based assay according to manufacturer’s procedure of
Techniques: Mutagenesis
Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Article Title: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
doi: 10.1080/14756366.2022.2157411
Figure Lengend Snippet: In vitro inhibition of mutant and wild type IDH2 enzymes by selected target compounds.
Article Snippet: Assay of IDH2 R140Q enzyme inhibition was performed using the fluorimetry-based assay according to manufacturer’s procedure of
Techniques: In Vitro, Inhibition, Mutagenesis
Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Article Title: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
doi: 10.1080/14756366.2022.2157411
Figure Lengend Snippet: Docking results and interacting residues for inhibitors, 6c , 6e , 7c , and enasidenib in IDH2 R140Q allosteric site (PDB ID: 5I96).
Article Snippet: Assay of IDH2 R140Q enzyme inhibition was performed using the fluorimetry-based assay according to manufacturer’s procedure of
Techniques:
Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Article Title: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
doi: 10.1080/14756366.2022.2157411
Figure Lengend Snippet: Binding interaction of enasidenib (A) and compounds 6c (B), 6e (C), and 7c (D) inside IDH2 R140Q allosteric site (PDB ID: 5I96). 2D pose binding of the compound (left), green lines (H-bond), pink lines (hydrophobic interactions), cyan lines (halogen bond), and 3D surface representation of the compound in the allosteric site (right).
Article Snippet: Assay of IDH2 R140Q enzyme inhibition was performed using the fluorimetry-based assay according to manufacturer’s procedure of
Techniques: Binding Assay
Journal: Journal of Enzyme Inhibition and Medicinal Chemistry
Article Title: Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents
doi: 10.1080/14756366.2022.2157411
Figure Lengend Snippet: Alignment of compounds 6c (dark red), 6e (blue), and 7c (orange) and enasidenib (green) in the IDH2 R140Q allosteric site viewing parallel layout.
Article Snippet: Assay of IDH2 R140Q enzyme inhibition was performed using the fluorimetry-based assay according to manufacturer’s procedure of
Techniques: